The Laboratory of Hematopoiesis and Stem Cell Research uses mouse models for studying hematopoiesis and hematopoietic tissues. The hematopoietic tissue has an enormous capacity to regenerate; therefore, our research is strongly relevant to regenerative medicine. Research is focused upon hematopoietic stem and progenitor cells (HSPCs). With the use of advanced flow and image cytometry techniques, combined with HSPCs transplantation, we try to identify the subpopulations of HSPCs involved in the early response to acute bone marrow damage. Moreover, with the use of molecular biology tools, we attempt to understand the molecular mechanisms activating the repopulation potential in these early response cells. We are also interested in the external cues emanating and present in the stroma of major hematopoietic tissues, the bone marrow and spleen, leading to the activation of HSPCs responding to tissue damage.